Daraasad cusub oo cinwaankeedu yahay "Isticmaalka Pix-2-Pix GAN ee ku salaysan Waxbarashada Qoto dheer ee PSMA PET/CT Attenuation Correction" ayaa dhawaan lagu daabacay Mugga 15 ee Oncotarget Maajo 7, 2024.
Soo-gaadhista shucaaca ee ka timaadda daraasadaha PET/CT ee isku xigxiga ee dabagalka bukaanka kansarka waa walaac. Baaritaankan dhowaan la sameeyay, koox cilmi-baarayaal ah oo ay ku jiraan Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, iyo Stephanie A. Harmon oo ka socda Machadka Kansarka Qaranka ee Machadyada Caafimaadka Qaranka ayaa soo bandhigay qalab sirdoon macmal ah (AI). Qalabkani wuxuu higsanayaa inuu soo saaro sawirro PET (AC-PET) oo la saxay oo laga soo qaaday sawirro PET (NAC-PET) oo aan la saxin, taasoo laga yaabo inay yareyso baahida loo qabo baaritaannada CT ee qiyaasta hoose.
"Sawirrada PET ee ay soo saarto AI waxay leeyihiin awood caafimaad oo lagu yareeyo baahida loo qabo sixitaanka yareynta sawir-qaadista CT-ga iyadoo la ilaalinayo calaamadaha tirada iyo tayada sawirka ee bukaanada kansarka qanjirka 'prostate'."
Hababka: Algorithm waxbarasho oo qoto dheer oo ku salaysan qaab-dhismeedka shabakadda isku-dhafka ah ee 2D Pix-2-Pix (GAN) ayaa lagu sameeyay iyadoo lagu saleynayo sawirrada AC-PET iyo NAC-PET ee la isku daray. Daraasadda PET-CT ee 18F-DCFPyL PSMA (antigen-ka xuubka gaarka ah ee qanjirka 'prostate') ee 302 bukaan oo qaba kansarka qanjirka 'prostate' ayaa loo qaybiyay kooxo tababar, ansaxin, iyo tijaabo ah (n 183, 60, iyo 59, siday u kala horreeyaan). Qaabka waxaa lagu tababaray iyadoo la adeegsanayo laba istaraatiijiyadood oo heeraysan: Qiimaha Heerka Sare (SUV) oo ku salaysan iyo SUV-NYUL oo ku salaysan. Waxqabadka toosan ee sawir-qaadista waxaa lagu qiimeeyay iyadoo la adeegsanayo khaladka celceliska celceliska laba jibbaaran ee caadiga ah (NMSE), khaladka celceliska (MAE), tusmada isku-ekaanshaha qaab-dhismeedka (SSIM) iyo saamiga calaamadda-ilaa-sawaaxa ugu sarreeya (PSNR). Dhakhtarka daawada nukliyeerka ayaa si lama filaan ah u sameeyay falanqayn heerka dhaawaca ah oo ku saabsan aagga xiisaha leh. Tilmaamayaasha SUV waxaa lagu qiimeeyay iyadoo la adeegsanayo isku-dhafka isku-xirka kooxda dhexdeeda (ICC), isku-dhafka ku celcelinta (RC), iyo moodooyinka saamaynta isku dhafan ee toosan.
Natiijooyinka:Kooxda baaritaanka madaxa-bannaan, dhexdhexaadka NMSE, MAE, SSIM, iyo PSNR waxay ahaayeen 13.26%, 3.59%, 0.891, iyo 26.82, siday u kala horreeyaan. ICC-da SUVmax iyo SUVmean waxay ahaayeen 0.88 iyo 0.89, taasoo muujinaysa xiriir xooggan oo u dhexeeya calaamadaha sawir-qaadista tirada ee asalka ah iyo kuwa AI-da soo saaray. Arrimaha sida goobta dhaawaca, cufnaanta (cutubyada Hounsfield), iyo qaadashada dhaawaca ayaa la ogaaday inay saameyn ku yeesheen khaladka qaraabada ah ee cabbirrada SUV-ga ee la soo saaray (dhammaan p < 0.05).
"AC-PET oo ay soo saartay qaabka Pix-2-Pix GAN waxay muujinaysaa cabbirrada SUV ee si dhow ula jaanqaadaya sawirradii asalka ahaa. Sawirrada PET ee AI-gu soo saaray waxay muujinayaan awood caafimaad oo rajo leh oo lagu yarayn karo baahida loo qabo baaritaannada CT-ga si loo saxo hoos u dhigista iyadoo la ilaalinayo calaamadaha tirada iyo tayada sawirka."
—— ...
Sida aan wada ognahay, horumarinta warshadaha sawir-qaadista caafimaadka lama kala saari karo horumarinta taxane qalab caafimaad ah - duritaanno wakiillo isbarbardhig ah iyo agabkooda taageerada - kuwaas oo si weyn looga isticmaalo goobtan. Shiinaha, oo caan ku ah warshadeeda wax soo saarka, waxaa jira soo-saareyaal badan oo caan ku ah gudaha iyo dibaddaba soo saarista qalabka sawir-qaadista caafimaadka, oo ay ku jiraanLnkMedTan iyo markii la aasaasay, LnkMed waxay diiradda saareysay cilmiga duritaanka wakiilada cadaadiska sare leh. Kooxda injineernimada ee LnkMed waxaa hogaaminaya Ph.D. oo leh in ka badan toban sano oo waayo-aragnimo ah waxayna si qoto dheer ugu hawlan yihiin cilmi-baarista iyo horumarinta. Isaga oo hagaya,Cirbad CT hal madax ah,Cirbad CT laba madax ah,Cirbadeeyaha wakiilka isbarbardhigga MRI, iyoCirbad dareere ah oo cadaadis sare ku shaqeeya oo loo yaqaan AngiographyWaxaa loogu talagalay sifooyinkan: jirka xooggan oo is haysta, is-dhexgalka hawlgalka ee ku habboon oo caqli badan, shaqooyinka dhammaystiran, amniga sare, iyo naqshad waara. Waxaan sidoo kale bixin karnaa irbado iyo tuubo la jaan qaadi kara noocyada caanka ah ee irbadaha CT, MRI, DSA. Iyada oo leh dabeecad daacad ah iyo xoog xirfadeed, dhammaan shaqaalaha LnkMed si daacad ah ayay idiinku martiqaadayaan inaad timaadaan oo aad si wadajir ah u sahamisaan suuqyo badan.
Waqtiga boostada: Maajo-14-2024
