Sawirkee ayaa waxtar badan u leh ogaanshaha soo noqoshada soo noqoshada biochemical ee kansarka qanjirka 'prostate': PET/CT ama mpMRI?

Marka loo eego falanqaynta meta-falan ee dhowaan, positron emission tomography/computed tomography (PET/CT) iyo multi-parameter magnetic resonance imaging (mpMRI) waxay bixiyaan heerar la mid ah ogaanshaha ogaanshaha kansarka qanjirka 'prostate' (PCa) soo noqnoqda.

Cilmi-baadhayaashu waxay ogaadeen in prostate-ka gaarka ah ee antigen (PSMA) PET/CT uu lahaa heerka ogaanshaha guud ee boqolkiiba 69 ee soo noqoshada kansarka qanjirka 'prostate', marka la barbardhigo 70 boqolkiiba mpMRI.

"[Dib-u-soo-noqoshada biochemical], labada habba way shaqeeyaan. Natiijooyinkayagu waxay muujinayaan in aysan jirin farqi weyn oo u dhexeeya guud ahaan DR (heerka ogaanshaha) ee u dhexeeya labada qaab sawireed, iyo mpMRI waa kharash badan oo wax ku ool ah iyada oo la ilaalinayo isla DR, "qoraaga daraasadda L. Xu, oo ku xiran Dugsiga Daawo Jaamacadda Hunan ee Daawada Dhaqanka Shiinaha, Hunan, Shiinaha iyo asxaabta.

Soo-noqnoqoshada PCa-ga maxalliga ah, qorayaasha daraasaddu waxay xuseen in DR On mpMRI uu 10% ka sarreeyay (62% vs. 52%). Cilmi-baadhayaashu waxay kaloo ogaadeen in PSMA PET/CT ay muujisay horumar dhan 18% DR Marka la ogaanayo metastasis-ka qanjidhada qanjidhada (50% iyo 32%, siday u kala horreeyaan). Si kastaba ha ahaatee, mid ka mid ah natiijooyinka ma ahayn mid muhiim ah, qorayaasha daraasadda ayaa yiri.

Cilmi-baadhayaashu waxay aaminsan yihiin in dareenka sare iyo gaar ahaaneed ay siin karaan PSMA PET/CT faa'iido u leh dejinta PCa iyo ogaanshaha nabarrada yaryar, laakiin sidoo kale waxay qirayaan in helitaanka habka uu yahay arrin. Multi-parameter MRI ayaa laga yaabaa inay ku caawiso ogaanshaha soo noqnoqoshada maxalliga ah iyo PCa-ga muhiimka ah ee kiliinikada, laakiin qorayaasha daraasaddu waxay qireen in kala duwanaanshiyaha interobserver laga yaabo inuu yahay arrin la xiriirta mpMRI.

Si kastaba ha ahaatee, natiijooyinka guud ee falanqaynta-metada waxay soo jeedinayaan in labada habba ay door ku leeyihiin ogaanshaha PCa BCR, oo tilmaamaya daraasadaha mustaqbalka ee mustaqbalka kuwaas oo bixin kara caddayn weyn oo arrintan ku saabsan.

Xu iyo asxaabtiisuba waxay carrabka ku adkeeyeen saamaynta wayn ee natiijooyinka daraasaddu ku leedahay ku-dhaqanka bukaan-socodka. Waxay tilmaameen in awoodaha ogaanshaha isbarbardhigga ee PSMA PET/CT iyo mpMRI ay muujinayaan waxtarka labada hab ee lagu ogaanayo BCR ee bukaannada PCa. Si kastaba ha ahaatee, waxay carrabka ku adkeeyeen baahida loo qabo cilmi-baaris dheeraad ah si loo qiimeeyo kartida, helitaanka, iyo waxtarka kharashka ee farsamooyinka sawir-qaadista.

Marka laga hadlayo xaddidaadda daraasadda, qorayaashu waxay qireen in cabbirka muunadda yar ee 290 bukaan ay tahay natiijada diiradda saaraya falanqaynta daraasadaha isbarbardhigga ah ee lagu ogaanayo BCR ee isla kooxaha bukaannada. Waxay sidoo kale kor u qaadeen suurtagalnimada eexda natiijooyinka sababtoo ah nidaamyada sawirada kala duwan iyo sifooyinka bukaanka ee lixda daraasadood ee ay dib u eegeen.

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Horumarinta tignoolajiyada sawirka caafimaadka, waxaa soo baxa shirkado badan oo keeni kara alaabada sawirka, sida cirbadaha iyo saliingadaha.LnkMedtignoolajiyada caafimaadka ayaa ka mid ah. Waxaan bixinaa faylal buuxa oo ah alaabada ogaanshaha caawinta:CT hal durid,CT duri madax labalaab ah,cirbadeynta MRIiyoDurida cadaadiska sare ee DSA. Waxay si fiican ula shaqeeyaan noocyo kala duwan oo CT/MRI scanner ah sida GE, Philips, Siemens. Ka sokow duritaanka, waxaanu sidoo kale bixinaa saliingaha iyo tuubada loo isticmaalo noocyada kala duwan ee duritaanka sida Medrad/Bayer, Mallinckrodt/Guerbet, Nemoto, Medtron, Ulrich.
Kuwa soo socda ayaa ah awoodeena asaasiga ah: waqtiyada dhalmada degdega ah; Shahaadooyin shahaado oo dhammaystiran, sannado badan oo waayo-aragnimo dhoofin ah, habka hubinta tayada ugu fiican, alaabada si buuxda u shaqeysa, si diiran ayaan u soo dhaweyneynaa weydiintaada.